Surfactant Protein D And C-Reactive Protein in patients with lower respiratory tract infections

In the world researches the role of destabilization of surfactant system of the lungs is being studied more and more often, as well the role of proteins being the part of it, and which play an important role in providing its stability. Considering that, the aim of our work was assessing diagnostic significance of surfactant protein D (SP-D) in patients with community acquired pneumonia (CAP) and infectious exacerbation of chronic obstructive pulmonary disease (IE COPD) as SP-D provides development of adequate immune response in the action of components of the outer environment and pathogens, being a marker of pathogenic microorganisms, destined to be destroyed by the immune system and being attractant for the immune cells, i. e. increases phagocytosis efficacy. Percentage ratio of infectious agents revealed in patients with CAP and IE COPD made up 37% and 45% correspondingly. Index of SP-D levels in patients of both groups with identification of causative agent and without it did not reliable difference (р=0,658; р=0,835). Plasma level of SP-D in patients with CAP and IE COPD was reliably higher as compared with control group (р=0,002; р 0,001). However, reliable difference between findings of patients with CAP and IE COPD was not revealed (р 0,144). Plasma level of C-RP was reliably higher in patients of both groups as compared with control group (р 0,001). C-RP level was reliably higher in patients with CAP relatively patients with IE COPD (р 0,001). Correlation link between C-RP and SP-D was not revealed, this is probably connected with various specificity of theses markers for infectious processes of the respiratory system. To our opinion, in diagnostic practice it is expedient to use SP-D and С-RP markers together to more fuller characteristics of the inflammatory process, both as systemic inflammatory response, and as characteristics of the degree of pulmonary tissue lesion, developing as a result of destabilization of lung surfactant system.